Prospective evaluation of symptom responses to successful operation for mild-moderate primary hyperparathyroidism.

Background: Parathyroidectomy is claimed to strongly improve the hypercalcemic symptoms in patients with primary hyperparathyroidism (HPT). The object of this study was to register the patients own experience of symptom changes in response to successful parathyroid surgery.

Methods: Material one. 44 HPT patients filled in a questionnaire consisting of 8 visual analogue scales referring to "typical" hypercalcemic symptoms before as well as 2 and 12 months after neck surgery. Their results were compared with those obtained from an age- and sex-matched group of patients undergoing surgery for non-toxic thyroid disease. Material two. 25 elderly women with mild-moderate HPT were followed more closely up to 3 years after neck surgery with the same type of questionnaire.

Results: HPT patients expressed significantly more of fatigue, muscular weakness, impaired memory, thirst and polyuria than patients with non-toxic thyroid disorders. These differences were eliminated 2 months after surgery. The pattern of response to parathyroidectomy was similar for most symptoms: an impressive improvement after 2 months and then a gradual return towards the preoperative value. However, the response was still significant for fatigue, weakness, thirst, polyuria and inactivity after 1 year. The effect of normalization of serum calcium on symptom scoring varied considerably between different individuals and also between different symptoms in the same individual. The elderly women responded in a similar biphasic way but their improvements were less pronounced.

Conclusions: HPT patients experience significant improvements of most "hypercalcemic" symtoms after successful parathyroidectomy, but the effects are transient and vary considerably between different individuals.