The authors report five cases of intrinsic duodenal obstruction in neonates, operated upon since 1976 to 1982. In 3 cases, it's a question of atresia and in two cases of annular pancreas. The associated lesions are in one case, a macrocephaly, in a second case, a microcephaly with ocular lesions and in a third case a jejunal atresia. The operating procedure consists four times in a duodeno-jejunostomy and one time in a duodeno-duodenostomy. A complementary jejunal resection with end-to-end anastomosis is necessary in the case of associated jejunal atresia. A discharge gastrostomy is performed once only. The post operative feeding is exclusively parenteral. A cholostatic jaundice appears in two cases but run its course favourably. The postoperative course is simple. There is no death. The five cases evolue normally at long term.