The objective of this article was to present possibilities of percutaneous gastrostomy for management of a newborn with esophageal and duodenal atresia. Percutaneous gastrostomy is the most commonly employed technique for providing long-term enteral nutrition. In adults, it is also method of choice for decompression of digestive tract in palliative treatment of malignant and non malignant diseases. This is a case report of two-day old newborn with esophageal atresia with distal tracheoesophageal fistula and duodenal atresia. Percutaneous decompressive gastrostomy was used as a temporary bridge to definite surgery for management of respiratory dysfunction of this newborn, caused by dilated stomach. Surgical management (esophageal and duodenal reconstructions) as well as intra- and postoperative period were without any complications. Three months after surgical management, the infant is well and without any difficulties.