Background: Combination of different intracranial tumors is an infrequent phenomenon. Combination of pituitary adenomas with craniopharyngiomas is extremely rare.

Objective: To present exceptionally rare combinations of pituitary adenomas and craniopharyngiomas.

Results: We present two patients with combinations of pituitary adenomas and adamantinomatous craniopharyngiomas. Due to topographic and anatomical features of neoplasms, combined access was used for resection of both tumors in the first case (transcallosal and transnasal in different surgeries). The second patient required simultaneous endoscopic transnasal resection of both tumors. Baseline symptoms (decreased vision in both cases and mental disorders in the first case) partially regressed, and patients were discharged.