Objective: To explore an effective treatment for extensive and multiple epidermodysplasia verruciformis (EV).

Methods: A 30-year-old female with a 10-year history of EV lesions underwent surgery to remove verrucous plaques and residual lesions, followed by photodynamic therapy once a week for three times.

Results: After a one-year follow-up, no recurrence was observed, and the patient was satisfied with the outcome.

Conclusion: Surgery combined with photodynamic therapy seems promising for treating extensive and multiple EV, but more research is needed for verification.