Changeable anterior chamber depth due to spontaneous zonular laxity of the lens is a rare abnormality in clinic. Here is a 25-year-old female with changeable anterior chamber depth due to bilateral spontaneous zonular laxity which also finally led to progressive myopia and angle-closure glaucoma is described. After using local anti-inflammation and dilation of the pupil, and carrying out "Phacoemulsification + anterior vitrectomy" putted intraocular lens (IOL) into the ravine of ciliary body, the woman's intraocular pressure was controlled and visual acuity was corrected to 20/20.