Objective: To investigate the clinical characteristics and associated risk factors of peripapillary intrachoroidal cavitation (PICC) in myopic eyes with open-angle glaucoma (OAG).

Methods: In this study, eyes of consecutive participants were categorized into the myopia only group and the myopia with OAG group. PICC was identified by radial scans centered on the optic disc using optical coherence tomography. The myopic maculopathy, optic disc morphology, and visual field defect were also assessed. The prevalence of PICC was compared between the two groups, and risk factors of PICC in the myopia with OAG group were investigated by multivariate logistic regression analysis.

Results: Of 775 enrolled myopic eyes with or without OAG, 58 eyes were found to have PICC. Compared with the myopia only group, the myopia with OAG group had a significantly higher prevalence of PICC (10.4% [44/422] vs 4.0% [14/353]) (P = 0.001). In the myopia with OAG group, participants with PICC were older and showed longer axial length, worse BCVA, more severe myopic fundus changes than those without PICC (all P < 0.01). Multivariate regression analysis showed that older age, optic disc tilt, inferior rotation of the optic disc, larger peripapillary atrophy, and posterior staphyloma were risk factors for PICC in the myopia with OAG group.

Conclusions: PICC was more prevalent in eyes with myopia and coexisting OAG than in eyes with myopia alone. And risk factors for the presence of PICC in eyes with myopia and coexisting OAG were older age and more severe myopic fundus changes.