Objective: To report the development of cystoid macular edema following the use of topical latanoprost in an eye with glaucoma and pseudophakia.

Methods: A 73-year-old woman with bilateral pseudophakia and glaucoma had been treated with topical carteolol hydrochloride and isopropyl unoprostone bilaterally. One month later the unoprostone was replaced by latanoprost bilaterally. After 1 month, the patient complained of decreased vision in the right eye, which had a history of surgical complications.

Results: Fluorescein angiography showed cystoid macular edema in the right fundus. The edema disappeared 2 weeks after the discontinuation of latanoprost. Cystoid macular edema did not develop in the left eye, which had no history of surgical complications.

Conclusions: These observations suggest that latanoprost may cause cystoid macular edema in an eye with a history of surgical complications.