Hypersensitivity vasculitis developed in a patient six days after therapy with terbutaline sulfate was initiated. The casual association between the drug and hypersensitivity vasculitis is based on the temporal relationship, a positive lymphocyte transformation test with terbutaline sulfate, and exclusion of other causes. This is, to the best of our knowledge, the first report of a leukocytoclastic vasculitic reaction to terbutaline sulfate.