Acute myocardial infarction (AMI) is infrequent in patients with idiopathic thrombocytopenic purpura (ITP) so the best treatment is not well known. The next case shows a 37-year-old man with chronic ITP who suffered an anterior AMI, the platelet count at admission was 39,000 microL. He was treated successfully with primary percutaneous angioplasty under anticoagulation with unfractionated heparin and antiaggregation with clopidogrel and ASA. At the end of the procedure we sealed the femoral access site with Angio-Seal(R). He didn t have any complications during the procedure and after six months remained asymptomatic. In some patients with chronic ITP and AMI the percutaneous treatment could be a good option.