A retrospective study of risk factors for thrombosis in patients with ITP.

Journal: Hematology (Amsterdam, Netherlands)
Published:
Abstract

ITP is not only a bleeding disease but also a potential thrombotic disease. This retrospective study analyzed the factors associated with the occurrence of thrombosis events in ITP patients. The overall incidence of thrombosis was 4.66% (15/322), with the incidence of arterial events was 2.17% (7/322) and of venous thrombosis was 2.80% (9/322). Thrombosis can occur in all stages and was more common in patients with chronic ITP (66.7%). In univariate logistic analysis, age (OR = 1.037, 95%CI (1.003,1.072), p = 0.032), hypertension (OR = 3.389, 95%CI (1.184,9.699), p = 0.023), coronary artery disease (OR = 10.714, 95%CI (2.462,46.619), p = 0.002), dyslipidemia (OR = 4.325, 95%CI (1.463,12.788), p = 0.008), and treatment with TPO-RAs (OR = 5.233, 95%CI (1.448,18.918), p = 0.012) were related to increased risk thrombotic events. In multivariate logistic analysis, results showed that coronary artery disease (OR = 9.486, 95% CI (1.858, 48.42), p = 0.007), dyslipidemia (OR = 3.983, 95% CI (1.255, 12.641), p = 0.019), as well as TPO-RAs treatment (OR = 4.591, 95% CI (1.238, 17.023), p = 0.023), were independent risk factors for thrombosis in ITP patients (p < 0.05). Thrombotic events can occur at all stages of ITP with a higher percentage in chronic ITP. Coronary artery disease, dyslipidemia and TPO-RAs treatment are independent risk factors related to thrombosis in ITP patients.

Authors
Fan Zhou, Shiqi Zhang, Renxia Li, Zhihui Feng, Dandan Wang, Jia Wang, Yaxian Tan, Wen Yang, Wei Zhang, Li Ma, Yanting Li, Chunlin Gao, Hui Bi, Zeping Zhou