Intussusception is a common surgical emergency in pediatric populations; however, its association with giant Meckel's diverticulum is exceedingly rare. This case report describes a unique presentation of retrograde ileo-ileal intussusception occurring in conjunction with a giant Meckel's diverticulum in a six-year-old boy.

Methods: A six-year-old male presented with signs of intestinal obstruction. Abdominal ultrasound revealed classic target signs, and the patient was taken for emergency laparotomy. Intraoperatively, a retrograde ileo-ileal intussusception into a giant Meckel's diverticulum was discovered, necessitating resection and end-to-end ileo-ileal anastomosis. The case underscores the diagnostic challenges associated with retrograde intussusception. In the discussion, a comparison is made with a similar report describing Meckel's diverticulum associated with internal hernia and volvulus (Al-Salem et al., 2021), emphasizing the spectrum of complications related to Meckel's diverticulum. This comparison highlights the novelty of our case in the context of pediatric intestinal emergencies.

Conclusions: This report highlights the need for a high index of suspicion in pediatric patients with intestinal obstruction and emphasizes that retrograde intussusception complicating giant Meckel's diverticulum, although rare, should be considered in the differential diagnosis.