Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study.
Journal: Journal Of Neuroimmunology
Published:
Abstract
To investigate the role of the matrix metalloproteinase-9 gene (MMP-9) in multiple sclerosis (MS), we analyzed the functional -1562C/T and -90 (CA)(n) repeat polymorphisms in 243 Italian patients with MS and 173 healthy controls. A significant increase of the -1562T allele carriers was found in patients with MS compared to controls. Moreover, haplotype analysis showed that the haplotype formed by the -1562T allele and the L allele ((CA)(
Authors
Antonella La Russa, Rita Cittadella, Elvira De Marco, Paola Valentino, Virginia Andreoli, Francesca Trecroci, Valeria Latorre, Antonio Gambardella, Aldo Quattrone
Relevant Conditions