The role of cannabinoid system on immune modulation: therapeutic implications on CNS inflammation.
Journal: Mini Reviews In Medicinal Chemistry
Published:
Abstract
There is a growing amount of evidence suggesting that cannabinoids may be neuroprotective in CNS inflammatory conditions. Advances in the understanding of the physiology and pharmacology of the cannabinoid system have increased the interest of cannabinoids as potential therapeutic targets. Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in cells of the immune system, as well as in brain glial cells. In the present review it is summarized the effects of cannabinoids on immune reactivity and on the regulation of neuroinflammatory processes associated with brain disorders with special attention to chronic inflammatory demyelinating diseases such as multiple sclerosis.
Authors
Fernando Correa, Leyre Mestre, Eduardo Molina Holgado, Angel Arévalo Martín, Fabian Docagne, Eva Romero, Francisco Molina Holgado, José Borrell, Carmen Guaza
Relevant Conditions