A Cross Sectional Study of the Systems Immunology and Viral Diversity of SARS-CoV2 Infection, COVID-19 Disease and Multisystem Inflammatory Syndrome in Children

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Objectives: To perform systems immunology and strain diversity among SARS-CoV2 and MIS-C infected children. Study design: Cross sectional study. Study population: Children attending outpatients units and admitted in wards in pediatric hospitals in Chennai. Main study parameters/endpoints: Immune responses in children with SARS-CoV2 infection and multisystem inflammatory syndrome in children (MIS-C) infection and its association of SARS-CoV2 viral diversity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1
Maximum Age: 15
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• Children between 1 to 15 years of age

• Willing to provide informed consent (parents)/assent

• For Group 1 - Positive or Negative for COVID-19 by RT-PCR but positive for SARS-CoV2 IgG

• For Group 2 - Positive for COVID-19 by RT-PCR but negative for SARS-CoV2 IgG

• For Group 3 - Positive for COVID-19 by RT-PCR or positive for SARS-CoV2 IgG antibody

• For Group 4 - Control children who are negative for both RT-PCR and IgG antibody

Locations
Other Locations
India
National Institute for Research in Tuberculosis
RECRUITING
Chennai
Contact Information
Primary
PAVAN KUMAR, PhD
pavankumarn@nirt.res.in
9940292543
Time Frame
Start Date: 2020-12-23
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 180
Treatments
Group 1
Prior SARS-CoV2 infection as defined by being positive for IgG
Group 2
COVID-19 disease as defined as children positive by RT-PCR
Group 3
Children with MIS-C according to the WHO or CDC criteria
Group 4
Control children who are negative for both RT-PCR and antibody
Related Therapeutic Areas
Severe Acute Respiratory Syndrome (SARS)
Multisystem Inflammatory Syndrome in Children (MIS-C)
COVID-19
Sponsors
Collaborators: National Institutes of Health (NIH)
Leads: Tuberculosis Research Centre, India

This content was sourced from clinicaltrials.gov

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