Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Journal: Bioorganic & Medicinal Chemistry Letters
Published:
Abstract
A series of benzazepinones were synthesized and evaluated as hNa(v)1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.
Authors
Scott Hoyt, Clare London, Hyun Ok, Edward Gonzalez, Joseph Duffy, Catherine Abbadie, Brian Dean, John Felix, Maria Garcia, Nina Jochnowitz, Bindhu Karanam, Xiaohua Li, Kathryn Lyons, Erin Mcgowan, D Macintyre, William Martin, Birgit Priest, Mchardy Smith, Richard Tschirret Guth, Vivien Warren, Brande Williams, Gregory Kaczorowski, William Parsons
Relevant Conditions