Varicella-zoster virus (VZV) reactivation from latently infected ganglia causes multiple neurologic diseases. The most common is herpes zoster, which is frequently complicated by postherpetic neuralgia, meningoencephalitis, and vasculopathy, including VZV temporal arteritis, myelopathy, and retinal necrosis. All of these disorders can develop without rash. Importantly, VZV vasculopathy is emerging as a significant cause of TIAs and stroke. In particular, a subset of patients who present with symptoms and signs of giant cell arteritis (GCA), but whose temporal artery biopsies are GCA-negative, have multifocal VZV vasculopathy with temporal artery infection. Herein we focus on the specific diagnostic and therapeutic challenges that clinical neurologists encounter in diseases caused by VZV, discuss guidelines for zoster vaccine, and highlight molecular features of VZV latency with a focus on preventing the serious neurologic and ocular complications of VZV reactivation.