Consensus Clinical Management Guideline for PLA2G6-Associated Neurodegeneration (PLAN).
Journal: Journal Of Child Neurology
Published:
Abstract
This clinical guideline provides recommendations for the evaluation and management of individuals with PLA2G6-associated neurodegeneration (PLAN). PLAN, a neurodegeneration with brain iron accumulation disorder, presents with infantile-onset (infantile neuroaxonal dystrophy), juvenile-onset, and adult-onset forms with motor, cognitive, ophthalmologic, and autonomic symptoms. This guideline was developed using a modified Delphi process with input from PLAN experts and family members of individuals with PLAN. A literature search was performed, although in the absence of data, recommendations were based on expert opinion. The guideline contains recommendations on diagnostic approach, disease-specific treatment, and symptom-based management.
Authors
Jenny Wilson, Audrey K Soo, Allison Gregory, Nardo Nardocci, Giovanna Zorzi, Matthew Ritzman, Amanda Hope, David Duncan, Megan Thomas, Serena Bertoldi, Natale Scalise, Patricia Wood, Heather Massey, Amber Denton, Amanda Sargent, Leena Panwala, Penelope Hogarth, Manju Kurian, Susan Hayflick
Relevant Conditions