Extramedullary solitary plasmocytoma (E.S.P.) is an undoubtedly rare neoplasm for the head and neck areas and even more for the larynx. The Authors take a case observed by them as a starting point for remarking its symptomatology and unforeseable development as well as various and unsteady histopathology. Afterwards they dwell upon the differential diagnosis with the multiple myeloma and the plasmacell granuloma. Such diagnosis is mainly suggested by the histopathological investigation with the support of clinical, blood and radiologic tests. The preferential treatment and the need of a long-term and careful follow-up are the suggested.