Plasmacytoma is a rare tumor of plasma cells with two primary variants: solitary bone plasmacytoma (SBP) and extramedullary plasmacytoma (EMP). It poses diagnostic challenges at times. Radiotherapy (RT) is the curative modality in the majority of cases. We share a case series with the aim of adding evidence to the literature about plasmacytoma and its clinical presentation, diagnostic challenges, and outcome with RT.