Solitary plasmocytoma is a rare plasmactic cell tumor occurring in the head and neck. These constitute, less than 1% of all head and neck malignancies. On initial presentation they must be differentiated from multiple myeloma. This may prove to be difficult because a varying percentage may be associated at a later date with the development of multiple myeloma. We describe three cases of plasmocytomas, one occurred in the larynx, in the cavity nasal and other in the skull base. The clinical characteristics, diagnosis criteria and therapeutic problems (radiation, surgery or a combination of booth) are discussed and reviewed in the literature.