CT findings of 2 patients with primary cerebral lymphoma were presented with a literature review of the CT manifestations of primary cerebral lymphoma. On the plain CT scan, most of lymphomas were either hyper- or isodense, well demarcated, and had variable surrounding edema. The tumors were mostly situated in the deep structures of brain: the basal ganglia, corpus callosum, periventricular white matter and vermis of cerebellum. On the postcontrast CT scan, cerebral lymphomas showed a homogeneous contrast enhancement. Ring enhancement, occasionally gyral enhancement also may be seen. On the CT scan, primary cerebral lymphomas were usually misdiagnosed as glioma, meningioma, metastases and abscess. The difference between lymphoma and the above lesions was discussed.