This report presents 2 cases of chronic progressive external ophthalmoplegia (CPEO) with progressive bilateral ptosis, managed successfully using Müller muscle-conjunctival resection with tarsectomy (MMCRT). The first case involved a 59-year-old female, and the second a 45-year-old male, both presenting with longstanding histories of worsening ptosis and significant limitations in extraocular motility. Postoperatively, both patients exhibited substantial improvements in eyelid elevation without complications such as lagophthalmos or exposure keratopathy, commonly seen in alternative surgical approaches. These cases demonstrate MMCRT as a promising technique for managing CPEO-related ptosis, highlighting its potential advantages and the need for further studies to confirm its efficacy and safety in broader clinical applications.