Clinical data of two cases of relapsing polychondritis were reported and the relative literatures were reviewed. The two patients diagnosed relapsing polychondritis after clinical and laboratory examinations.The first case was mild , no larynx and trachea involvement, and her condition improved and controlled after glucocorticoid treatment;The second case which involved larynx and trachea caused breathing difficulty. Two years later he died of lung infection and respiratory failure despite a variety of treatment methods. Relapsing polychondritis is very easily misdiagnosed, early diagnosis and treatment can slow the progression of the disease, for patients with violations of the larynx and trachea should pay close attention to disease progression, tracheotomy or place endotracheal memory alloy stent when necessary.