Purpose: This retrospective observational study aimed to investigate the self-reported prevalence of seizure clusters (SCs) in patients with epilepsy (PWE) and its relationship with clinical characteristics.

Methods: We retrospectively analyzed data from consecutive PWE from our hospital in northeastern China. Data were collected from the databank of a tertiary epilepsy center. Logistic regression models were employed to investigate the relationships between the individual patient demographic/clinical variables and the occurrence of SC.

Results: In total, 606 consecutive PWE were included in the final analysis, and 268 (44.2%) patients experienced at least one seizure cluster. In multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002-1.027; p = 0.02), seizure frequency (OR: 2.08; 95% CI: 1.555-2.783; p < 0.001), multiple seizure types (OR: 5.111; 95% CI: 1.737-15.043; p = 0.003), number of current anti-seizure medications (ASM) (OR: 1.533; 95% CI: 1.15-2.042; p = 0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159-3.407; p = 0.013), and a history of status epilepticus (OR: 1.903; 95% CI: 1.24-2.922; p = 0.003) were independent variables associated with a history of SC in PWE.

Conclusion: Seizure clusters (SCs) are common occurrences at our study center. The occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.