A Randomized Prospective Study Between STN-DBS and GPi-DBS in Meige Syndrome

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Deep-brain stimulation (DBS) is an effective treatment for patients with Meige syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are both accepted targets for this treatment. Researchers designed this study to compare the 12-month outcomes for patients who undergo bilateral stimulation of the GPi or STN.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 75
Healthy Volunteers: f
View:

• Primary Meige syndrome was diagnosed by an experienced neurologist.

• All patients had received systematic and regular treatment for at least 1 year before surgery, including oral drugs and local injection of botulinum toxin A, but the efficacy was not apparent, as the ability to engage with daily life and the quality of life of the patients significantly decreased.

• Tere were no other serious systemic diseases, such as severe organic heart disease, severe lung, liver and kidney dysfunction, and coagulation dysfunction.

• Tere was no history of neurological diseases other than Meige syndrome, such as Parkinson's disease or severe cognitive dysfunction.

• Tere were no serious psychiatric disorders, such as schizophrenia.

• Preoperative head magnetic resonance imaging (MRI) examinations were normal. Patients of missing follow-up and incomplete clinical data were excluded from the cases.

Locations
Other Locations
China
Chao Zhang
RECRUITING
Jinan
Contact Information
Primary
chao zhang
chao_zhang@sdu.edu.cn
053182166631
Time Frame
Start Date: 2023-11-30
Estimated Completion Date: 2025-11-30
Participants
Target number of participants: 100
Treatments
Placebo_comparator: Bilateral STN deep brain stimulation
Patients with Meige syndrome accepted STN DBS
Experimental: Bilateral GPi deep brain stimulation
Patients with Meige syndrome accepted GPi DBS
Sponsors
Leads: Qilu Hospital of Shandong University

This content was sourced from clinicaltrials.gov