The serratus posterior superior intercostal plane block (SPSIPB) is a novel regional anesthesia technique providing broad dermatomal coverage. We present 2 patients who underwent coronary artery bypass grafting via median sternotomy and received bilateral SPSIPB for postoperative analgesia. Both patients exhibited effective pain control with low numeric rating scale scores and minimal morphine consumption (8 mg and 10 mg, respectively) within the first 24 postoperative hours, without any complications. These findings support the potential role of SPSIPB as a safe and effective component of multimodal analgesia in cardiac surgery, particularly in patients at increased risk for neuraxial techniques. .