Although the current literature points to surgical complication as the most common cause of entero-cutaneous fistulae, the formation of a colo-cutaneous fistula following a microdiscectomy is an unusual complication. Derivation of iatrogenic fistulae is rare, however, can carry increased rates of patient mortality and may require definitive surgical intervention. The authors present a clinical manifestation of a colo-cutaneous fistula between the descending colon and lumbosacral back wound from a previous microdiscectomy.