A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
Journal: Molecular Genetics And Metabolism
Published:
Abstract
This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).
Authors
Zhenyan Fu, Tomohiro Nakayama, Naoyuki Sato, Yoichi Izumi, Yuji Kasamaki, Atsushi Shindo, Masakatsu Ohta, Masayoshi Soma, Noriko Aoi, Mikano Sato, Yukio Ozawa, Yitong Ma, Koichi Matsumoto, Nobutaka Doba, Shigeaki Hinohara
Relevant Conditions