Association on the haplotypes of CYP4F2 gene and myocardial infarction

Objective: The aim of this study was to assess the association between human CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study. A separate analysis on gender was also carried out.

Methods: There were 250 MI patients and 250 control subjects genotyped for 5 SNPs of the human CYP4F2 gene (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). Data were assessed on 3 separate groups: the total subjects, men and women.

Results: For men, G allele was significantly higher in the MI patients than in the control subjects and the overall distribution of the haplotypes was significantly different between the MI patients and the control subjects (P=0.002). Also in men, the frequency of T-C-G haplotype was significantly higher for MI patients than for control subjects (P=0.002), and the frequency of T-C-A haplotype was significantly lower for MI patients than for control subjects (P=0.003).

Conclusions: Data from the present results indicated that MI was associated with G allele of rs2108622 in men, suggesting that T-C-G haplotype might serve as genetic marker for MI in men.