It takes three: A cocktail of protists, bacterial sphingolipids and an inflammasome.

Journal: Cell Host & Microbe
Published:
Abstract

Symbiotic relationships between mammalian hosts and their flora impact host immunity and disease. In this issue, Winsor and colleagues define a trans-kingdom interaction, which protects against colorectal cancer. Tritrichomonas protists initiate a Bacteroides bloom and sphingolipid release, which activates the NLRP6 inflammasome, enhancing protective mucus secretion by sentinel goblet cells.

Authors
Michael Grigg, Eliza Alves Ferreira
Relevant Conditions

Colorectal Cancer

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