Chronic Antibody-Mediated Rejection Symptoms, Doctors, Treatments, Advances & More

Chronic Antibody-Mediated Rejection Overview

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Learn About Chronic Antibody-Mediated Rejection

What is the definition of Chronic Antibody-Mediated Rejection?

Chronic antibody-mediated rejection (AMR) is a human leukocyte antigen (HLA) antibody-induced major complication that occurs after solid organ (kidney, lung, pancreas, and intestinal) transplantation that causes ongoing graft injury and graft loss. Chronic antibody-mediated rejection usually occurs more than one year after transplant.

What are the symptoms of Chronic Antibody-Mediated Rejection?

Symptoms of chronic antibody-mediated rejection can depend on the type of organ transplanted; however, the condition is characterized by endothelial cell changes, microvascular inflammation, C4d (complement protein splitting), circulating donor-specific antibodies, fibrosis, graft dysfunction, and probable graft loss. Patient symptoms may also include dyspnea (difficult breathing), cough, fever, malaise, or they may be asymptomatic.

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What are the current treatments for Chronic Antibody-Mediated Rejection?

Currently, there are few therapies that can prevent and reverse chronic antibody-mediated rejection. However, patients are often treated with a range of therapies, such as plasma exchange (PLEX); intravenous immunoglobulin (IVIG); complement inhibitors, such as eculizumab and rituximab; pulse steroids; imlifidase; anti-thymocyte globulin (ATG); or other T-cell-depleting antibodies; the proteasome inhibitor, bortezomib; cyclophosphamide; interleukin-6 inhibitors, and a triple immunosuppressants protocol, which includes mycophenolic acid, tacrolimus, and steroids.

Who are the top Chronic Antibody-Mediated Rejection Local Doctors?

Elite in Chronic Antibody-Mediated Rejection

Yoshihiko Watarai

Elite in Chronic Antibody-Mediated Rejection

Yoshihiko Watarai

Nagoya, JP

Yoshihiko Watarai practices in Nagoya, Japan. Mr. Watarai and is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are ABO Incompatibility, Chronic Antibody-Mediated Rejection, Hyperparathyroidism, Kidney Transplant, and Splenectomy.

Elite in Chronic Antibody-Mediated Rejection

Takaaki Kobayashi

Elite in Chronic Antibody-Mediated Rejection

Takaaki Kobayashi

Nagakute, JP

Takaaki Kobayashi practices in Nagakute, Japan. Kobayashi and is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. Their top areas of expertise are ABO Incompatibility, Chronic Antibody-Mediated Rejection, Hypercalcemia, Kidney Transplant, and Splenectomy.

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Distinguished in Chronic Antibody-Mediated Rejection

Dr. Josef Oberholzer

Transplant Surgery | General Surgery

Distinguished in Chronic Antibody-Mediated Rejection

Dr. Josef Oberholzer

Transplant Surgery | General Surgery

1 Hospital Dr Barringer Wing, 1st Floor,

Charlottesville, VA

434-924-9370

Languages Spoken:

English, Spanish

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Josef Oberholzer is a Transplant Surgeon and a General Surgeon in Charlottesville, Virginia. Dr. Oberholzer and is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are Chronic Antibody-Mediated Rejection, End-Stage Renal Disease (ESRD), Obesity, Islet Cell Transplantation, and Pancreas Transplant.