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Learn About Hemophagocytic Lymphohistiocytosis

What is the definition of Hemophagocytic Lymphohistiocytosis?
Hemophagocytic lymphohistiocytosis (HLH) is a condition in which the body makes too many activated immune cells (macrophages and lymphocytes). Symptoms may include fever, enlarged liver or spleen, cytopenia (decreased number of blood cells), and neurological abnormalities. HLH may be inherited in an autosomal recessive manner or it can have non-genetic causes in which case it is called acquired HLH. Each subtype is caused by a change in a different gene. The genetic cause of type 1 is currently unknown. Types 2-5 are caused by genetic changes in the PRF1 gene, the UNC13D gene, the STX11 gene and the STXBP2 gene, respectively. When HLH results from an inappropriate immune response to Epstein-Barr virus or another viral illness, it may be due to a separate genetic condition called X-linked lymphoproliferative disease (XLP). XLP is caused by a genetic change in the SH2D1A or XIAP gene and is inherited in an X-linked manner.
What are the alternative names for Hemophagocytic Lymphohistiocytosis?
  • Familial hemophagocytic lymphohistiocytosis
  • FHL
  • Familial HLH
  • Familial erythrophagocytic lymphohistiocytosis
  • Familial histiocytic reticulosis
  • HLH
Who are the top Hemophagocytic Lymphohistiocytosis Local Doctors?
Franco M. Locatelli
Elite in Hemophagocytic Lymphohistiocytosis
Elite in Hemophagocytic Lymphohistiocytosis
Rome, IT 

Franco Locatelli practices in Rome, Italy. Mr. Locatelli and is rated as an Elite expert by MediFind in the treatment of Hemophagocytic Lymphohistiocytosis. His top areas of expertise are Acute Lymphoblastic Leukemia (ALL), Leukemia, Juvenile Myelomonocytic Leukemia (JMML), Bone Marrow Transplant, and Splenectomy.

Naval G. Daver
Elite in Hemophagocytic Lymphohistiocytosis
Hematology Oncology | Oncology | Hematology
Elite in Hemophagocytic Lymphohistiocytosis
Hematology Oncology | Oncology | Hematology

MD Anderson

2130 W Holcombe Blvd, Life Sciences Plaza, 
Houston, TX 
Languages Spoken:
English
Offers Telehealth

Naval Daver is a Hematologist Oncology specialist and an Oncologist in Houston, Texas. Dr. Daver and is rated as an Elite provider by MediFind in the treatment of Hemophagocytic Lymphohistiocytosis. Their top areas of expertise are Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), Leukemia, Bone Marrow Aspiration, and Bone Marrow Transplant.

 
 
 
 
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Elite in Hemophagocytic Lymphohistiocytosis
Pediatric Hematology Oncology
Elite in Hemophagocytic Lymphohistiocytosis
Pediatric Hematology Oncology

Children's Hospital Medical Center

3333 Burnet Ave, 
Cincinnati, OH 
Languages Spoken:
English

Michael Jordan is a Pediatric Hematologist Oncology provider in Cincinnati, Ohio. Dr. Jordan and is rated as an Elite provider by MediFind in the treatment of Hemophagocytic Lymphohistiocytosis. His top areas of expertise are Hemophagocytic Lymphohistiocytosis, Non-Langerhans-Cell Histiocytosis, Histiocytosis, Bone Marrow Transplant, and Osteotomy.

What are the latest Hemophagocytic Lymphohistiocytosis Clinical Trials?
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Frontline Ruxolitinib With De-Intensified HLH-94 for Adult Hemophagocytic Lymphohistiocytosis (HLH): A Multicenter, Single-Arm Phase 2 Study

Summary: This phase II trial tests the effects of ruxolitinib in combination with a de-intensified HLH-94 drug regimen has on patients with newly diagnosed hemophagocytic lymphohistiocytosis (HLH), a disorder caused by dysregulated immune responses (that is, immune responses that are too strong and cause inflammatory damage to normal tissues). The therapy used for HLH decreases the activity of the immune s...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Hemophagocytic Lymphohistiocytosis?