Hepatic Venoocclusive Disease with Immunodeficiency Overview

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Learn About Hepatic Venoocclusive Disease with Immunodeficiency

What is the definition of Hepatic Venoocclusive Disease with Immunodeficiency?
Hepatic veno-occlusive disease with immunodeficiency (VODI) is a genetic disorder of the liver and immune system that appears before the age of 12 months in which the small veins of the liver become blocked.
What are the symptoms of Hepatic Venoocclusive Disease with Immunodeficiency?
Symptoms of veno-occlusive disease with immunodeficiency may include failure to thrive, abnormally small head, liver enlargement, fibrosis of the liver, recurrent bacterial and opportunistic infections, diarrhea, anemia, fluid in the abdomen (ascites), seizures, weakness on one side of the body (hemiparesis), leg paralysis (paraplegia), lung fibrosis, lung hemorrhage, recurrent pneumonia, recurrent ear infections, yellowing of the skin, mucous membranes, and whites of eyes (jaundice), low platelets, urinary retention, portal hypertension (high blood pressure), liver abnormalities, fibrosis of the heart, and liver failure. Most individuals with veno-occlusive disease with immunodeficiency do not survive childhood, while a few may survive into early adulthood.
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What are the current treatments for Hepatic Venoocclusive Disease with Immunodeficiency?
Treatment for veno-occlusive disease with immunodeficiency include intravenous immunoglobulin (IVIG), pneumocystis jeroveci (fungal infection) prophylaxis, treatment for infections, and liver transplantation in selected patients.
Who are the top Hepatic Venoocclusive Disease with Immunodeficiency Local Doctors?
Robert J. Soiffer
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Dr. Robert J. Soiffer
Oncology | Hematology
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Dr. Robert J. Soiffer
Oncology | Hematology

Dana-Farber Cancer Institute, Inc.

450 Brookline Ave, 
Boston, MA 
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Robert Soiffer is an Oncologist and a Hematologist in Boston, Massachusetts. Dr. Soiffer and is rated as an Elite provider by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. His top areas of expertise are Graft Versus Host Disease (GvHD), Hepatic Venoocclusive Disease with Immunodeficiency, Chronic Graft Versus Host Disease (cGvHD), Bone Marrow Transplant, and Bone Graft. Dr. Soiffer is currently accepting new patients.

Joseph H. Antin
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Dr. Joseph H. Antin
Oncology | Hematology | Transplant Surgery
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Dr. Joseph H. Antin
Oncology | Hematology | Transplant Surgery

Dana-Farber Cancer Institute, Inc.

450 Brookline Ave, 
Boston, MA 
617-632-3000
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Joseph Antin is an Oncologist and a Hematologist in Boston, Massachusetts. Dr. Antin and is rated as an Elite provider by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. His top areas of expertise are Graft Versus Host Disease (GvHD), Chronic Graft Versus Host Disease (cGvHD), Hepatic Venoocclusive Disease with Immunodeficiency, Bone Marrow Transplant, and Bone Marrow Aspiration. Dr. Antin is currently accepting new patients.

 
 
 
 
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Antonio Pagliuca
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Antonio Pagliuca
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Antonio Pagliuca
Denmark Hill, 
London, ENG, GB 

Antonio Pagliuca practices in London, United Kingdom. Mr. Pagliuca and is rated as an Elite expert by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. His top areas of expertise are Hepatic Venoocclusive Disease with Immunodeficiency, Aspergillosis, Graft Versus Host Disease (GvHD), Bone Marrow Transplant, and Endoscopy.

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What are the latest Hepatic Venoocclusive Disease with Immunodeficiency Clinical Trials?
Prospective Multi Center Study of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS)
Prospective Multi Center Study of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS)
Enrollment Status: Recruiting
Publish Date: April 20, 2025
Intervention Type: Other

Summary: This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the HCT setting as a contributor of significant morbidity and mortality.

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Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
Enrollment Status: Recruiting
Publish Date: December 04, 2024
Intervention Type: Diagnostic test

Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for people with severe blood-related diseases. However, it comes with serious risks, including a condition called graft-versus-host disease (GVHD), where the transplanted cells attack the patient's body. GVHD can occur in about 50% of patients acutely and 35% in a chronic form, potentially affecting organs like th...

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