Learn About Kawasaki Disease
Kawasaki disease is a sudden and time-limited (acute) illness that affects infants and young children. Affected children develop a prolonged fever lasting several days, a skin rash, and swollen lymph nodes in the neck (cervical lymphadenopathy). They also develop redness in the whites of the eyes (conjunctivitis) and redness (erythema) of the lips, lining of the mouth (oral mucosa), tongue, palms of the hands, and soles of the feet.
The causes of Kawasaki disease are not well understood. The disorder is generally regarded as being the result of an abnormal immune system activation, but the triggers of this abnormal response are unknown. Because cases of the disorder tend to cluster geographically and by season, researchers have suggested that an infection may be involved. However, no infectious agent (such as a virus or bacteria) has been identified.
In the United States and other Western countries, Kawasaki disease occurs in approximately 1 in 10,000 children under 5 each year. The condition is 10 to 20 times more common in East Asia, including Japan, Korea, and Taiwan.
A predisposition to Kawasaki disease appears to be passed through generations in families, but the inheritance pattern is unknown. Children of parents who have had Kawasaki disease have twice the risk of developing the disorder compared to the general population. Children with affected siblings have a tenfold higher risk.
Jane Newburger is a Pediatric Cardiologist and a Cardiologist in Boston, Massachusetts. Dr. Newburger and is rated as an Elite provider by MediFind in the treatment of Kawasaki Disease. Her top areas of expertise are Multisystem Inflammatory Syndrome in Children (MIS-C), Congenital Heart Disease (CHD), Kawasaki Disease, Heart Transplant, and Thrombectomy. Dr. Newburger is currently accepting new patients.
Jane Burns is a Pediatrics provider in San Diego, California. Dr. Burns and is rated as an Elite provider by MediFind in the treatment of Kawasaki Disease. Her top areas of expertise are Kawasaki Disease, Multisystem Inflammatory Syndrome in Children (MIS-C), Pediatric Myocarditis, and DRESS Syndrome.
Adriana Tremoulet is a Pediatric Infectious Disease specialist and an Infectious Disease provider in San Diego, California. Dr. Tremoulet and is rated as an Elite provider by MediFind in the treatment of Kawasaki Disease. Her top areas of expertise are Multisystem Inflammatory Syndrome in Children (MIS-C), Kawasaki Disease, Pediatric Myocarditis, and Severe Acute Respiratory Syndrome (SARS).
Summary: Based on a population pharmacokinetic model-based dose optimization study, a 15 mg-equivalent, age-, and bodyweight-adjusted dosing regimen for Chinese children with giant coronary artery aneurysms after Kawasaki disease was proposed. This single-center, single-arm, pilot study aims to evaluate the feasibility of the 15 mg-equivalent dosing regimen within a limited sample size. Patients will be fo...
Summary: CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures for rare diseases. The CoRDS team works with patient advocacy groups, in...
Published Date: September 01, 2015
Published By: National Institutes of Health