A Study to Determine the Prevalence and Clinical Characteristics Associated With PKD1 Gene Variant Groups in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Status: Recruiting
Location: See all (23) locations...
Study Type: Observational
SUMMARY
The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 65
Healthy Volunteers: f
View:
• Estimated glomerular filtration rate (eGFR) greater than or equal to (≥) 30 milliliter per minute (mL/min)/1.73 m\^2
• Willing and able to comply with scheduled visits and other study procedures
• A pre-existing diagnosis of ADPKD as defined in the protocol
Locations
United States
Alabama
Alabama Kidney Research
RECRUITING
Alabaster
California
Kaiser Permanente - Los Angeles Medical Center
RECRUITING
Los Angeles
Connecticut
DaVita Clinical Research
RECRUITING
Middlebury
Yale Nephrology Clinical Research Clinic
RECRUITING
New Haven
Florida
Nature Coast Clinical Research - Inverness
RECRUITING
Inverness
Georgia
Emory School of Medicine - Renal Division
RECRUITING
Atlanta
Renal Associates, LLC
RECRUITING
Columbus
Iowa
University of Iowa Hospital & Clinics
RECRUITING
Iowa City
Kansas
University of Kansas Medical Center
RECRUITING
Kansas City
Massachusetts
Tufts Medical Center
RECRUITING
Boston
Maryland
General Clinical Research Center, University of Maryland Baltimore
RECRUITING
Baltimore
Michigan
Quest Research Institute
SUSPENDED
Farmington Hills
Nevada
DaVita Clinical Research
RECRUITING
Las Vegas
New York
Columbia University Medical Center
RECRUITING
New York
Other Locations
Belgium
Universitaire Ziekenhuizen Leuven
RECRUITING
Leuven
Canada
McGill University Health Centre, Glen Site
RECRUITING
Montreal
France
Hopital de la Cavale Blanche
RECRUITING
Brest
Necker Hospital
RECRUITING
Paris
Puerto Rico
FDI Clinicial Research
RECRUITING
San Juan
United Kingdom
King's College Hospital
RECRUITING
London
Royal Free NHS Trust
RECRUITING
London
St Georges University Hospitals NHS Foundation Trust
RECRUITING
London
Sheffield Kidney Institute, Northern General Hospital
RECRUITING
Sheffield
Contact Information
Primary
Medical Information
medicalinfo@vrtx.com
617-341-6777
Time Frame
Start Date: 2024-12-19
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 400
Treatments
Part A
Eligible participants will complete a single visit to complete a blood sample collection for PKD1/2 genotyping.
Part B
Participants who have completed all assessments in Part A and have a subset of variants in PKD1 will complete 1 year of follow-up.
Related Therapeutic Areas
Sponsors
Leads: Vertex Pharmaceuticals Incorporated