Learn About Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a kidney disorder passed down through families. In this disease, many cysts form in the kidneys, causing them to become enlarged.
Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD
PKD is passed down through families (inherited). The two inherited forms of PKD are autosomal dominant and autosomal recessive.
People with PKD have many clusters of cysts in the kidneys. What exactly triggers the cysts to form is unknown.
PKD is associated with the following conditions:
- Aortic aneurysms
- Brain aneurysms
- Cysts in the liver, pancreas, and testes
- Diverticula of the colon
As many as half of people with PKD have cysts in the liver.
Symptoms of PKD may include any of the following:
- Abdominal pain or tenderness
- Blood in the urine
- Excessive urination at night (nocturia)
- Flank pain on one or both sides
- Drowsiness
- Joint pain
- Nail abnormalities
The goal of treatment is to control symptoms and prevent complications. Treatment may include:
- Blood pressure medicines
- Diuretics (water pills)
- Low-salt diet
Any urinary tract infection should be treated quickly with antibiotics.
Cysts that are painful, infected, bleeding, or causing a blockage may need to be drained. There are usually too many cysts to make it practical to remove each cyst.
Surgery to remove one or both kidneys may be needed. Treatments for end-stage kidney disease may include dialysis or a kidney transplant.
Mayo Clinic
Neera Dahl is a Nephrologist in Rochester, Minnesota. Dr. Dahl and is rated as an Elite provider by MediFind in the treatment of Polycystic Kidney Disease. Her top areas of expertise are Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease, Chronic Kidney Disease, Kidney Stones, and Kidney Transplant. Dr. Dahl is currently accepting new patients.
University Medical Associates Of The Medical University Of South Carol
Prabhakar Baliga is a General Surgeon in Charleston, South Carolina. Dr. Baliga and is rated as a Distinguished provider by MediFind in the treatment of Polycystic Kidney Disease. His top areas of expertise are Polycystic Kidney Disease, End-Stage Renal Disease (ESRD), Chronic Antibody-Mediated Rejection, Kidney Transplant, and Liver Transplant. Dr. Baliga is currently accepting new patients.
Mayo Clinic
Vicente Torres is a Nephrologist in Rochester, Minnesota. Dr. Torres and is rated as an Elite provider by MediFind in the treatment of Polycystic Kidney Disease. His top areas of expertise are Autosomal Dominant Polycystic Kidney Disease, Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney Disease, Kidney Transplant, and Nephrectomy. Dr. Torres is currently accepting new patients.
More information and support for people with polycystic kidney disease and their families can be found at a kidney disease support group.
The disease gets worse slowly. Eventually, it may lead to end-stage kidney failure. It is also associated with liver disease, including infection of liver cysts.
Treatment may relieve symptoms for many years.
People with PKD who don't have other diseases may be good candidates for a kidney transplant.
Health problems that may result from PKD include:
- Anemia
- Bleeding or rupture of cysts
- Long-term (chronic) kidney disease
- End-stage kidney disease
- High blood pressure
- Infection of liver cysts
- Kidney stones
- Liver failure (mild to severe)
- Repeated urinary tract infections
Contact your health care provider if:
- You have symptoms of PKD
- You have a family history of PKD or related disorders and you are planning to have children (you may want to have genetic counseling)
Currently, no treatment can prevent the cysts from forming or enlarging.
Summary: The purpose of this study is to estimate the prevalence, demographic, and clinical characteristics of PKD1/2 gene variant groups in the ADPKD population.
Summary: Hepato-renal fibrocystic diseases (HRFD) is a term developed that encompasses rare diseases such as Autosomal Recessive Polycystic Kidney Disease (ARPKD), and other diseases with common features (Joubert syndrome, Bardet Biedl syndrome, Meckel-Gruber syndrome, congenital hepatic fibrosis (CHF), Caroli syndrome (CS), polycystic liver disease, oro-facial-digital syndrome, nephronophithisis (NPHP), a...
Published Date: August 28, 2023
Published By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Arnaout MA. Cystic kidney diseases. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 112.
Torres VE, Harris PC. Cystic diseases of the kidney. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 45.