We report 3 patients with polychondritis who also developed spondyloarthropathy: one B27 negative patient with ankylosing spondylitis (AS) who also exhibited uveitis and optic neuritis; a B27 positive patient with AS who developed acute aortic insufficiency and Crohn's disease; and a B27 negative patient with Reiter's syndrome. The possible association of spondyloarthropathy with relapsing polychondritis is discussed.