Severe Combined Immunodeficiency (SCID) Overview

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Learn About Severe Combined Immunodeficiency (SCID)

What is the definition of Severe Combined Immunodeficiency (SCID)?
Severe combined immunodeficiencies (SCID) are inherited immune system disorders characterized by abnormalities with responses of both T cells and B cells (specific types of white blood cells needed for immune system function). Common signs and symptoms include an increased susceptibility to infections including ear infections; pneumonia or bronchitis; oral thrush; and diarrhea. Due to recurrent infections, children with SCID do not grow and gain weight as expected (failure to thrive). SCID may be caused by genetic changes in any of several genes and can be inherited in an X-linked recessive (most commonly) or autosomal recessive manner. The most common type of SCID is called X-linked Severe combined immunodeficiency (XSCID). Another form of SCID is caused by a deficiency of the enzyme adenosine deaminase (ADA).
What are the alternative names for Severe Combined Immunodeficiency (SCID)?
  • Severe combined immunodeficiency
  • SCID
Who are the top Severe Combined Immunodeficiency (SCID) Local Doctors?
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Morton J. Cowan
Pediatric Allergy and Immunology | Pediatrics
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Morton J. Cowan
Pediatric Allergy and Immunology | Pediatrics
505 Parnassus Ave, 
San Francisco, CA 
415-476-2188
Languages Spoken:
English
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Morton Cowan is a Pediatric Allergy and Immunologist and a Pediatrics provider in San Francisco, California. Dr. Cowan and is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Severe Combined Immunodeficiency (SCID), X-Linked Severe Combined Immunodeficiency, Chronic Granulomatous Disease, Splenectomy, and Thymectomy.

Elite in Severe Combined Immunodeficiency (SCID)
Dr. Robert A. Sokolic
Hematology Oncology | Hematology | Oncology
Elite in Severe Combined Immunodeficiency (SCID)
Dr. Robert A. Sokolic
Hematology Oncology | Hematology | Oncology
593 Eddy St, 
Providence, RI 
401-444-5391
Languages Spoken:
English

Robert Sokolic is a Hematologist Oncology specialist and a Hematologist in Providence, Rhode Island. Dr. Sokolic and is rated as an Elite provider by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Severe Combined Immunodeficiency (SCID), Adenosine Deaminase Deficiency, Chronic B-Cell Leukemia (CBCL), Sickle Cell Disease, and Bone Marrow Transplant.

 
 
 
 
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Andrew R. Gennery
Elite in Severe Combined Immunodeficiency (SCID)
Andrew R. Gennery
Elite in Severe Combined Immunodeficiency (SCID)
Andrew R. Gennery
Queen Victoria Road, 
Newcastle Upon Tyne, ENG, GB 

Andrew Gennery practices in Newcastle Upon Tyne, United Kingdom. Mr. Gennery and is rated as an Elite expert by MediFind in the treatment of Severe Combined Immunodeficiency (SCID). His top areas of expertise are Severe Combined Immunodeficiency (SCID), Primary Immunodeficiency (PID), Chronic Granulomatous Disease, Bone Marrow Transplant, and Heart Transplant.

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What are the latest Severe Combined Immunodeficiency (SCID) Clinical Trials?
The Determination of Genetic Basis Of Immunodeficiency
The Determination of Genetic Basis Of Immunodeficiency
Enrollment Status: Recruiting
Publish Date: June 17, 2025

Summary: This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study. Candidates include: * Patients with diminished numbers of T cells or NK cells or both, or * Patients with normal T cell and NK cell numbers but diminished T cell, B cell, or NK cell function. Relatives of patients wil...

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Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Lentiviral Gene Transfer for Treatment of Children Older Than 2 Years of Age With X-Linked Severe Combined Immunodeficiency
Who is this study for: Child to adult male patients with Severe Combined Immune Deficiency
Enrollment Status: Recruiting
Publish Date: June 17, 2025
Intervention Type: Biological, Drug
Study Drugs: Palifermin, Busulfan, Autologous CD34-Positive VSV-G Pseudotyped CL20-4i-EF1a-hyc-OPT Vector Hematopoietic Stem Cell Infusion
Study Phase: Phase 1/Phase 2

Summary: This is a Phase I/II non-randomized clinical trial of ex vivo hematopoietic stem cell (HSC) gene transfer treatment for X-linked severe combined immunodeficiency (XSCID, also known as SCID-X1) using a self-inactivating lentiviral vector incorporating additional features to improve safety and performance. The study will treat 35 patients with XSCID who are between 2 and 50 years of age and who have...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center