The Mpox virus, formerly known as Monkeypox, was declared a Public Health Emergency of International Concern in July 2022 due to its rapid global spread. By 2024, the more virulent and fatal Clade Ib variant had reached the United States. While Mpox typically presents with a self-limited rash, severe manifestations requiring surgical intervention have become increasingly prevalent, necessitating heightened awareness and preparedness among surgeons.This narrative review, specifically targeting surgeons, provides a comprehensive summary of the current data on the epidemiology, pathophysiology, perioperative considerations, and surgical management of Mpox-related conditions. It outlines essential hospital protocols and perioperative precautions to mitigate nosocomial spread, drawing useful parallels with measures established for COVID-19. It also addresses Mpox-related surgical pathologies, including colorectal abscesses, cutaneous scarring, facial lesions, and ocular complications, detailing management strategies for each.Our findings emphasize the need for rigorous infection control measures, early recognition of surgical indications, and interdisciplinary coordination to optimize patient outcomes, especially since Mpox is most readily transmitted among immunocompromised individuals, such as those who have undergone solid organ transplants. The virus primarily spreads through sexual transmission and contact with infected skin lesions, necessitating standardized hospital protocols to minimize its spread, particularly in operating rooms. Colorectal manifestations often require surgical drainage, with colostomy being necessary in severe cases, while ophthalmic manifestations demand prompt and aggressive management to preserve vision. Airway management and anesthetic planning are also critical considerations in cases involving oropharyngeal Mpox lesions.This review highlights the urgent need for ongoing documentation and research to refine surgical management protocols for Mpox, enhancing preparedness for future outbreaks. The complexity and severity of Mpox-related surgical pathologies underscore the necessity for further studies to refine management strategies, develop innovative treatments, and improve patient outcomes. Future research should aim to deepen our understanding of Mpox pathophysiology and optimize protocols to ensure safe and effective care for affected patients. This is essential in an era marked by the threat of emerging infectious diseases and the lessons learned from recent global health crises.